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Silver sulfadiazine (CF-100) binds to deoxyribonucleic acid (DNA) but not to ribonucleic acid (RNA). DNA degradation is not observed. Nucleic acid and protein synthesis are not inhibited by silver sulfadiazine in cell-free systems. Conformational changes in the DNA are observed as evidenced by altered thermal transition, suggesting that silver sulfadiazine is inhibiting DNA replication.
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Wysor et al. (2008) studied this question.
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