• The total amount of body potassium can change tremendously without disturbing potassium metabolism. Potassium depletion, a decrease in content in relation to capacity, usually results from gastrointestinal and renal loss with inadequate intake. Potassium excess, usually a decrease in capacity rather than an increase in total body potassium, occurs in the presence of renal failure. Changes in the serum potassium concentration reflect changes in body need.
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James M. Burnell (1957) studied this question.
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