Key result
The QPatch automated patch-clamp system provides a high-throughput method to study voltage-gated sodium channel function and pharmacology for ion channel drug discovery.
Automated patch-clamp technologies like QPatch provide high-throughput and accurate methods for studying ion channel function in drug discovery.
QPatch protocol enables high-throughput Na(v) studies; leaves open validation for cardiovascular drug discovery pipelines.
Voltage-gated sodium (Na(v)) channels are highly sensitive to membrane potential and have fast gating kinetics. Patch clamp electrophysiology has long been the gold standard for studying these channels. Combining high throughput with high information content/accuracy, automated patch clamp technologies have emerged as critical tools in ion channel drug discovery. Described in this unit is the use of QPatch, one of the automated patch clamp systems, to study Na(v) channel function and pharmacology.
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Yi Liu (2014) studied this question. QPatch HT automated patch-clamp system was evaluated. The QPatch automated patch-clamp system provides a high-throughput method to study voltage-gated sodium channel function and pharmacology for ion channel drug discovery.
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