2-Phenacylpyridines (2) were prepared from 2-(tri-methylsilylmethy1)pyridine (A) and p-substituted benzonitriles ( ) (X = H, C1, CH3, 0CH3) in high yields (70 ' i .99%) under a mild condition (LDA/THF, -75 'C) .The method was compared with a reaction of a-picoline with (2) under the same condition.The keto-en01 tautomerism of (2) were also discussed by means of the nmr spectra.
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Konakahara et al. (1980) studied this question.