α‐AMINOCYCLIC AND BICYCLIC ALKANE CARBOXYLIC ACIDS: DIFFERENTIAL EFFECTS ON SELECTED AMINO ACIDS OF RAT BRAIN CORTEX1

The intraperitoneal administration of 1‐aminocyclopentane carboxylic acid, 1‐aminocyclohex‐ane carboxylic acid, l‐aminocycloheptane carboxylic acid, 1‐aminocyclooctane carboxylic acid, exo‐2‐aminobicyclo(2,2. l)heptane‐2‐carboxylic acid. endo‐2‐aminobicyclo(2,2.1)heptane‐2‐carboxylic acid. 2‐aminobicyclo(2.2.2)octane‐2‐carboxylic acid and 2‐aminobicyclo(3,2.l)octane‐2‐carboxylic acid to 18‐day‐old male rats selectively perturbed the levels of neutral amino acids in the cerebral cortex. While the effect of the above compounds was rather diversified and usually resulted in a reduction of amino acid levels. marked elevations of the levels of valine and isoleucine were also noted. 1‐Aminocycloheptane and cyclooctane carboxylic acids were particularly noteworthy, in that they elicited a marked reduction of the levels of cortical phenylalanine.