In Vitro Mineralization of Silicon Containing Calcium Phosphate Bioceramics

In vitro mineralization of silicon containing calcium phosphate (Si‐CaP) bioceramics was investigated in the constant‐composition double‐diffusion (CCDD) device under physiological conditions. The experiments were performed with porous pellets made of Si‐CaP, which was synthesized from Ca(NO 3 ) 2 ·4H 2 O, NH 4 H 2 PO 4 , ammonia and fumed silica according to a newly developed single‐stage preparation route. Twice as condensed aqueous solutions of the Kokubo's revised simulated body fluid (rSBF) were used as mineralizing medium. All samples of Si‐CaP bioceramics possessed excellent in vitro mineralizing properties and, therefore, this material is ready for further trials with cells. Simultaneously, the workability of the CCDD device in a less condensed (twofold instead of the previously used fourfold) aqueous solutions of rSBF was confirmed.