Key result
A theoretical anisotropic elastic model demonstrates that during severe vasoconstriction, the nonlinear elasticity of the vessel wall causes a Rayleigh-type instability leading to a periodic sausage-string pattern.
Model suggests mechanical basis for sausage-string patterns in vasoconstriction; hypothesis-generating and requires experimental validation before clinical consideration.
A new Rayleigh-type instability is proposed to explain the ``sausage-string'' pattern of alternating constrictions and dilatations formed in blood vessels under influence of a vasoconstricting agent. Our theory involves the nonlinear elasticity characteristics of the vessel wall, and provides predictions for the conditions under which the cylindrical form of a blood vessel becomes unstable.
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Alstrøm et al. (1999) studied High blood pressure. Vasoconstricting agent (e.g., Angiotensin II) was evaluated on Instability of the cylindrical form of blood vessels. A theoretical anisotropic elastic model demonstrates that during severe vasoconstriction, the nonlinear elasticity of the vessel wall causes a Rayleigh-type instability leading to a periodic sausage-string pattern.
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