Key result
This is a protocol for a network meta-analysis evaluating prophylactic inotropes for pediatric congenital heart disease surgery, with no results reported.
Why the study?
To compare the efficacy and safety of different prophylactic medications and generate a clinically useful ranking for preventing low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease.
Do prophylactic inotropes prevent low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease?
Meta-Analysis
Do prophylactic inotropes prevent low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease?
This is a protocol for a network meta-analysis to evaluate the efficacy and safety of prophylactic inotropes in pediatric congenital heart surgery.
Answers are grounded in this paper and cite their sources.
Evidence on prophylactic inotropes for pediatric CHD surgery remains inconclusive; this protocol will extend synthesis of LCOS and mortality data.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: 1. To compare in a network meta‐analysis the efficacy and safety of different prophylactic medications either against no treatment, or placebo, or against each other (as mono‐ or combination prophylaxis) for the prevention of low cardiac output syndrome and mortality for paediatric patients undergoing surgery for congenital heart disease. 2. To generate a clinically useful ranking of prophylactic medications (mono‐ and combination prophylaxis) according to efficacy and safety.
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Burkhardt et al. (2020) conducted a meta-analysis in congenital heart disease. prophylactic medications (inotropes) vs. no treatment, placebo, or each other was evaluated on low cardiac output syndrome and mortality. This is a protocol for a network meta-analysis evaluating prophylactic inotropes for pediatric congenital heart disease surgery, with no results reported.
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