What question did this study set out to answer?

Elucidate the primary amino acid sequence and chemical structure of the novel lantibiotic peptide actagardine.

January 1, 1990The Journal of AntibioticsOpen Access

Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy.

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Elucidate the primary amino acid sequence and chemical structure of the novel lantibiotic peptide actagardine.
Employed multiple homonuclear two-dimensional proton nuclear magnetic resonance (1H NMR) spectroscopic techniques to resolve the peptide structure.
Determined that actagardine is a 19-residue, tetracyclic peptide antibiotic.
Identified distinct structural sequence variations that differentiate actagardine from previously described lanthionine-containing peptide antibiotics.

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Implication

Spectroscopic analysis reveals the 19-residue tetracyclic structure of actagardine, highlighting unique structural features distinct from known lantibiotic peptide antibiotics.

Cite This Study

KETTENRING et al. (1990) studied this question.

synapsesocial.com/papers/6a9d6c91651e357600bf100e https://doi.org/10.7164/antibiotics.43.1082

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Implication

Spectroscopic analysis reveals the 19-residue tetracyclic structure of actagardine, highlighting unique structural features distinct from known lantibiotic peptide antibiotics.

Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy.

Key Points

Discussion

Implication

Cite This Study

Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy.

Key Points

Discussion

Implication

Cite This Study

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