Key result
Magnesium sulphate significantly attenuated hemodynamic stress responses, including heart rate and blood pressure, during laparoscopic abdominal surgeries compared to normal saline (p<0.05).
Why the study?
Does magnesium sulphate attenuate hemodynamic stress responses in patients undergoing laparoscopic abdominal surgeries?
RCT (n=62)
Double-blind
randomly divided
Does magnesium sulphate attenuate hemodynamic stress responses in patients undergoing laparoscopic abdominal surgeries?
Pre-pneumoperitoneum administration of magnesium sulphate effectively attenuates perioperative hemodynamic stress responses during laparoscopic abdominal surgeries.
Answers are grounded in this paper and cite their sources.
Supports pre-pneumoperitoneum magnesium sulphate to blunt hemodynamic surges in laparoscopic abdominal surgery; confirms RCT benefit versus saline.
Introduction: This randomized, double-blind, prospective study was undertaken to evaluate the effect of magnesium sulphate in attenuating the stress responses associated with laparoscopic abdominal surgeries. Methods: 62 patients who underwent laparoscopic abdominal surgery were randomly divided in to two groups, group I and group II. 5 minutes after intubation but before creation of pneumoperitoneum, the magnesium group (group I) received magnesium sulphate 50 mg/kg diluted in normal saline to total volume of 20 ml at 240 ml/hour over 5 minutes. The control group (group II) received same amount of normal saline. Results: Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were significantly less in group I with p<0.05. Train of four had no statistical significance. Extubation time was more in Group I but had no statistical significance. Conclusion: magnesium sulphate attenuates hemodynamic stress response in laparoscopic abdominal surgeries.
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Dar et al. (2015) conducted an RCT in Laparoscopic abdominal surgery (n=62). Magnesium sulphate vs. Normal saline was evaluated on Hemodynamic stress responses (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) (p=<0.05). Magnesium sulphate significantly attenuated hemodynamic stress responses, including heart rate and blood pressure, during laparoscopic abdominal surgeries compared to normal saline (p<0.05).
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