A novel, rapid, and simple capillary electrophoresis (CE) method has been developed for the determination of aspirin by on‐line treatment with alkali. Such on‐line reaction with 0.20 mol/L NaOH solution for 2.5 min at 45°C automatically and reproducibly converts aspirin into its hydrolysis product salicylic acid. Analysis is carried out in less than 12 min after conversion of aspirin in a flow injection (FI) system coupled to a CE instrument via a split‐flow interface cell, and a sampling frequency of 9 h–1 is achievable. The on‐line conversion method has been used to determine aspirin in four commercial pharmaceutical preparations, and the results are satisfactory.
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Chen et al. (2003) studied this question.
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