Practical preparation of polytosylated γ-cyclodextrins, octakis(6-O-tosyl)-2-O-tosyl-γ-cyclodextrin, octakis(6-O-tosyl)-γ-cyclodextrin, and heptakis(6-O-tosyl)-γ-cyclodextrin, has been established. The procedure involves reaction of γ-cyclodextrin with tosyl chloride in pyridine and column chromatographic separation using silica gel modified with 3-aminopropyl groups.
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Yamamura et al. (1993) studied this question.
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