Polysubstituted 4-(phenoxymethyl)-3-pyrrolines and their isomeric 4-(phenoxymethylene)pyrrolidines have been prepared by sequential one-pot coupling of three components: a propargylamine, a vinyl sulfone (or nitroalkene) and a phenolic derivative. The methodology is based on the sequential integration of a Cu-catalysed cycloaddition and a Pd-catalysed allylic substitution reaction. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
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Clique et al. (2002) studied this question.
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