Key result
Soaking the device foam in a thrombin solution did not change the frequency of residual shunting 24 hours after catheter closure of persistent ductus arteriosus.
Why the study?
Does soaking the Rashkind umbrella occluder device in thrombin solution reduce residual shunting at 24 hours in patients undergoing catheter closure of persistent ductus arteriosus?
Cohort (n=117)
Does soaking the Rashkind umbrella occluder device in thrombin solution reduce residual shunting at 24 hours in patients undergoing catheter closure of persistent ductus arteriosus?
Soaking the foam of the Rashkind umbrella occluder in thrombin solution does not reduce the frequency of residual shunting 24 hours after catheter closure of persistent ductus arteriosus.
Thrombin soaking does not reduce residual shunting after PDA closure; leaves open whether device modifications improve outcomes in future studies.
Catheter occlusion of the persistent ductus arteriosus recently became clinically available with a Rashkind (USCI Bellerica, Massachusetts, USA) umbrella occluder system. A few patients, however, had residual left to right shunting after the procedure. The impact of soaking the foam of the device in a thrombin solution to enhance clotting and of using a device with a diameter of 12 or 17 mm was assessed in 117 consecutive patients undergoing catheter closure. The frequency of residual shunting detected by colour flow Doppler 24 hours after the procedure was the same whether or not thrombin was used.
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Vitiello et al. (1991) conducted a cohort in Persistent ductus arteriosus (n=117). Soaking device foam in thrombin solution vs. No thrombin was evaluated on Residual shunting detected by colour flow Doppler 24 hours after the procedure. Soaking the device foam in a thrombin solution did not change the frequency of residual shunting 24 hours after catheter closure of persistent ductus arteriosus.
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