Sperm motility is one of the most important semen parameters affecting the fertility of an individual. Sp-cAMP, a thiophosphate analogue of c-AMP, is a phosphodiesterase inhibitor controlling the intracellular c-AMP levels which in turn influences sperm motility. The results in our laboratory on a group of suspected subfertile men and fertile donors showed significant enhancement of sperm motility after incubation of washed sperm with various doses of Sp-cAMP.
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Agarwal et al. (2009) studied this question.
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