SUMMARY A sequential study was carried out on the interaction of passive antibodies and age with infectious bursal disease virus (IBDV) infection. Chickens with high levels of passive antibodies were protected from bursal atrophy and immunosuppression, and their active immune response to IBDV was inhibited. As their passive antibodies waned, their active immune response increased. Chickens with passive antibodies were protected from immunosuppression for up to 4 weeks, while protection against bursal atrophy lasted for only 1 or 2 weeks. Infection with IBDV suppressed the immune response to Salmonella pullorum antigen in chickens 4 weeks old or younger. The response to bovine serum albumin was suppressed only in 1- and 2-week-old chickens.
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Lucio et al. (1980) studied this question.
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