Key result
A 20-year-old male developed Ewing sarcoma in the adrenal gland as a secondary malignancy two years after achieving complete remission from Stage IV Burkitt lymphoma with chemotherapy.
Case Report (n=1)
This is the first reported case of Ewing sarcoma occurring in the adrenal gland as a secondary malignancy in a survivor of Burkitt lymphoma treated with specific chemotherapy.
May signal rare secondary sarcomas in Burkitt lymphoma survivors; leaves open need for targeted long-term surveillance studies.
The occurrence of Ewing sarcoma as a secondary malignancy is an extremely rare event in long-term cancer survivors. In addition, the occurrence of Ewing sarcoma in the adrenal gland is highly unusual. In this case report, we treated a 20-year-old male patient with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and methotrexate and cytarabine chemotherapy following a diagnosis of Stage IV Burkitt lymphoma. Following complete remission, he had been maintained for 2 years without evidence of disease. However, a regular follow-up computed tomography scan found a left adrenal gland mass and a biopsy revealed positive membrane-localized mic-2 expression (CD99) and the presence of the translocation of the EWSR1 gene. To our knowledge, this is the first case report of Ewing sarcoma occurring in the adrenal gland of a patient who was treated with cyclophosphamide, doxorubicin, vincristine, dexamethasone/methotrexate and cytarabine chemotherapy for Burkitt lymphoma.
No takes yet. Share an insight, caveat, or question.
Lim et al. (2013) conducted a case report in Ewing sarcoma as a secondary malignancy (n=1). Cyclophosphamide, doxorubicin, vincristine, dexamethasone, methotrexate, and cytarabine chemotherapy was evaluated. A 20-year-old male developed Ewing sarcoma in the adrenal gland as a secondary malignancy two years after achieving complete remission from Stage IV Burkitt lymphoma with chemotherapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: