Key result
A 37-year-old woman with eosinophilia-myalgia syndrome experienced repeated coronary artery spasm, potentially mediated by toxic eosinophil proteins or focal myocardial lesions.
Case Report (n=1)
Highlights a potential mechanism of coronary vasospasm involving toxic eosinophil proteins in a patient with eosinophilia-myalgia syndrome.
No immediate clinical implications; leaves open eosinophil protein-mediated spasm as a hypothesis in eosinophilia-myalgia syndrome.
We report a case of repeated coronary artery spasm with myocardial injury in a 37-year-old woman with the eosinophilia-myalgia syndrome. This patient did not have a medical history of cardiac-related illness or risk factors for coronary artery disease. The presence of eosinophil granule major basic protein in otherwise normal-appearing myocardial tissue, along with normal plasma levels of tryptophan metabolites, suggests that the mechanism of vasospasm in this patient might involve toxic eosinophil proteins or focal myocardial lesions, but not the production of excess tryptophan metabolites.
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Phillip A. Hertzman (1992) conducted a case report in Eosinophilia-myalgia syndrome (n=1). Eosinophilia-myalgia syndrome was evaluated on Repeated coronary artery spasm with myocardial injury. A 37-year-old woman with eosinophilia-myalgia syndrome experienced repeated coronary artery spasm, potentially mediated by toxic eosinophil proteins or focal myocardial lesions.
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