Key result
The longer human ZAP isoform containing the PARP-like domain inhibited Semliki Forest virus infection by almost 10-fold, compared to 2-fold inhibition by the shorter isoform.
Population
Preclinical models including HeLa cells, 293T cells, and primate ZAP sequences
Comparison
Expression of human ZAP isoform containing the… vs Expression of human ZAP(S) isoform or rat NZAP
Design
Preclinical
Authors
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Longer ZAP isoform shows enhanced antiviral activity in models; leaves open human therapeutic relevance pending validation.
The longer human ZAP isoform containing a PARP-like domain, which evolved under positive selection, exhibits significantly stronger antiviral activity against retroviruses and alphaviruses than the shorter isoform.
Kerns et al. (2008) studied Viral infection (alphaviruses and retroviruses). Human ZAP(L) isoform (PARP-containing) vs. Human ZAP(S) isoform or rat NZAP was evaluated on Viral restriction (infectivity assays). The longer human ZAP isoform containing the PARP-like domain inhibited Semliki Forest virus infection by almost 10-fold, compared to 2-fold inhibition by the shorter isoform.
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