Key result
Statin therapy was independently associated with a reduced likelihood of suboptimal blood pressure control in adult diabetic patients (OR 0.5; 95% CI 0.26-0.96; P=0.037).
Why the study?
Does statin therapy improve blood pressure control in adult diabetic patients?
Cross-Sectional (n=425)
Yes
Does statin therapy improve blood pressure control in adult diabetic patients?
Odds Ratio: 0.5 (95% CI 0.26–0.96)
p-value: p=0.037
In adult diabetic patients in Uganda, statin therapy is associated with a 50% reduced odds of suboptimal blood pressure control.
May inform statin use in diabetic patients; leaves open causal BP effects pending prospective trials.
Background: Hypertension is one of the recognized risk factors of cardiovascular diseases in adult diabetic patients. High prevalence of suboptimal blood pressure (BP) control has been well documented in the majority of studies assessing BP control in diabetic patients in sub-Saharan Africa. In Uganda, there is a dearth of similar studies. This study evaluated the prevalence and correlates of suboptimal BP control in an adult diabetic population in Uganda. Patients and methods: This was a cross-sectional study that enrolled 425 eligible ambulatory adult diabetic patients attending three urban diabetic outpatient clinics over 11 months. Data about their sociodemographic characteristics and clinical history were collected using pre-tested questionnaires. Suboptimal BP control was defined according to the 2015 American Diabetes Association standards of diabetes care guideline as BP levels ≥140/90 mmHg. Results: The mean age of the study participants was 52.2±14.4 years, with the majority being females (283, 66.9%). Suboptimal BP control was documented in 192 (45.3%) study participants and was independently associated with the study site (private hospitals; odds ratio 2.01, 95% confidence interval 1.18–3.43, P =0.01) and use of statin therapy (odds ratio 0.5, 95% confidence interval 0.26–0.96, P =0.037). Conclusion: Suboptimal BP control was highly prevalent in this study population. Strategies to improve optimal BP control, especially in the private hospitals, and the use of statin therapy should be encouraged in adult diabetic patients.
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Lumu et al. (2017) conducted a cross-sectional in diabetes (n=425). statin therapy vs. no statin therapy was evaluated on suboptimal blood pressure control (≥140/90 mmHg) (OR 0.5, 95% CI 0.26-0.96, p=0.037). Statin therapy was independently associated with a reduced likelihood of suboptimal blood pressure control in adult diabetic patients (OR 0.5; 95% CI 0.26-0.96; P=0.037).
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