Why the study?
Are there ethnic differences in the hemodynamic mechanisms (specifically SVR) of ambulatory blood pressure regulation between African Americans and whites?
Are there ethnic differences in the hemodynamic mechanisms (specifically SVR) of ambulatory blood pressure regulation between African Americans and whites?
Systemic vascular resistance plays a more prominent role in the regulation of ambulatory blood pressure during routine daily activities in African Americans compared to whites.
Ethnic differences in SVR-BP links should not yet guide therapy; leaves open targeted trials in African Americans.
BACKGROUND: African Americans typically exhibit greater systemic vascular resistance (SVR) than do white individuals in response to laboratory challenges that raise blood pressure (BP). However, ethnic differences in ambulatory blood pressure (ABP) regulation have not been examined. METHODS: We monitored ABP in a sample of 10 African American and 10 white men and women. Ambulatory cardiac impedance monitoring was used to assess cardiac output and SVR concurrently with each ABP reading. RESULTS: We found that SVR was a significant predictor of daily ABP variations in African Americans (P <.01) but not in whites. CONCLUSIONS: For African Americans, SVR may play a more prominent role than for whites in the regulation of ABP during routine daily activities.
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Andrew Sherwood (2003) studied this question.
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