The influence of wet and dry granulation methods on the pore structure of lactose tablets

The conditions of wet granulation influenced the pore structure of lactose tablets, prepared over a wide range of tabletting pressures. Dry granulation, on the other hand, only influenced pore structure when slugging pressures were high, the granules were coarse and tabletting pressures were low. Mercury porosimetry revealed intense granule fragmentation when dry granulated materials were compressed. The effect of the change of pore size distribution on liquid penetration into tablets is discussed.