Quality Control Guidelines for MIC Susceptibility Testing of Omiganan Pentahydrochloride (MBI 226), a Novel Antimicrobial Peptide

Antimicrobial cationic peptides are thought to be an important self-defense mechanism against infectious agents for plants, animals, and bacterial species (2).While cationic peptides vary in their mechanisms of action, most are reactive with bacterial cytoplasmic membranes (2).Omiganan pentahydrochloride (formerly MBI 226), a novel topical mammal-derived antimicrobial peptide (sequence: ILRWPWWPWRRK-amide), acts by disrupting the cytoplasmic membranes of both grampositive and -negative bacteria, resulting in depolarization and cell death (D.