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April 1, 1992DNA and Cell Biology

Variable Region Sequence Analysis of Anti-DNA Antibodies: Evidence for a Family of Closely Related Germ-Line V H Genes Encoding Lupus Autoantibodies

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Authors

MFMary H. FosterDuke UniversityMMMichael P. MadaioMid Coast HospitalKBK J BarrettTufts University

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Foster et al. (1992) studied this question.

synapsesocial.com/papers/6a9d9f25f025b578bcd9c8fbhttps://doi.org/10.1089/dna.1992.11.175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus.1987 · 81 citations
  2. 2VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies1991 · 34 citations
  3. 3VH sequence of a human anti-Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes.1989 · 141 citations
  4. 4Ig VH gene family repertoire of plasma cells derived from lupus-prone MRL/lpr and MRL/++ mice.1989 · 22 citations
  5. 5Systemic autoimmune disease arises from polyclonal B cell activation.1987 · 309 citations