Key result
Policosanol plus aspirin significantly increased the proportion of patients achieving a favorable stroke outcome (mRSs ≤1) at 24 weeks compared to placebo plus aspirin (93.5% vs 6.7%, p<0.0001).
Why the study?
Does policosanol added to aspirin improve neurological recovery in patients with recent ischemic stroke?
RCT (n=61)
Double-blind
Randomized
No
Does policosanol added to aspirin improve neurological recovery in patients with recent ischemic stroke?
The addition of policosanol to aspirin therapy significantly improved neurological recovery and reduced oxidative stress markers in patients with recent ischemic stroke.
Answers are grounded in this paper and cite their sources.
Supports adjunctive policosanol with aspirin for ischemic stroke recovery; extends RCT evidence on combination therapy.
Background. Oxidative stress (OS) contributes to brain reperfusion injury after ischemic stroke. Policosanol, a mixture of 8 higher aliphatic sugarcane wax alcohols, has shown to protect against experimental brain ischemia.
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Javier Sánchez (2013) conducted an RCT in Ischemic stroke (n=61). Policosanol plus Aspirin vs. Placebo + Aspirin 125 mg/day was evaluated on Favourable stroke outcome (mRSs ≤1) at 24 weeks (p=<0.0001). Policosanol plus aspirin significantly increased the proportion of patients achieving a favorable stroke outcome (mRSs ≤1) at 24 weeks compared to placebo plus aspirin (93.5% vs 6.7%, p<0.0001).
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