Key result
Adult-onset asthma was associated with reduced right ventricular global longitudinal strain compared to controls (-20.3 vs -21.5; p=0.007), despite normal standard echocardiography parameters.
Why the study?
Studies evaluating the effect of asthma on cardiac functions are limited, leaving the association between adult-onset asthma and cardiac dysfunction unclear.
Does adult-onset asthma cause subclinical cardiac dysfunction detectable by speckle tracking echocardiography?
Case-Control (n=166)
Does adult-onset asthma cause subclinical cardiac dysfunction detectable by speckle tracking echocardiography?
Speckle tracking echocardiography reveals subclinical right ventricular dysfunction in patients with newly-diagnosed adult-onset asthma who otherwise have normal standard echocardiographic parameters.
Answers are grounded in this paper and cite their sources.
Suggests possible subclinical RV involvement in adult-onset asthma; leaves open whether strain imaging refines prognosis or management.
Objective There is limited number of studies on the effect of asthma disease on cardiac functions. The aim of this study was to investigate if there was any association between adult onset asthma and cardiac dysfunction.Methods Total of 83 nonsmoking adult onset asthma patients aged between 18 and 65, and 83 control subjects with comparable age and sex distribution were included in the study.None of the subjects had any chronic cardiovascular or systemic diseases.Two-dimensional, M-mode and tissue Doppler examinations were performed. STE analysis was obtained using the QLAB software. Complete blood count and high-sensitive C-reactive protein (hsCRP) levels were measured.Results There was no difference between two groups in terms of standard echocardiography and Doppler parameters. While tricuspid annular plane systolic excursion (TAPSE) was observed to be lower in asthmatics (24.9 ± 2.0 vs. 25.5 ± 2.1, p = 0.043), right ventricular myocardial performance index (RV MPI) was higher (0.36 ± 0.07 vs 0.32 ± 0.06, p˂0.001). There was no significant difference between the groups in terms of left ventricular STE parameters. Measurements of right ventricular global longitudinal strain (RVGLS) and right ventricular free wall strain (RVfree) were observed to be lower in the asthma group (-20.3 ± 2.9 vs −21.5 ± 2.9, p = 0.007; −24.0 ± 3.0 vs 25.1 ± 2.9, p = 0.009, respectively).Conclusion -We demonstrated that while adult onset mild-stage asthma patients have normal parameters in standard echocardiography, they have reduced right ventricular functions by STE.
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Baysal et al. (2020) conducted a case-control in Adult-onset asthma (n=166). Adult-onset asthma vs. Healthy controls was evaluated on Right ventricular global longitudinal strain (RVGLS) (p=0.007). Adult-onset asthma was associated with reduced right ventricular global longitudinal strain compared to controls (-20.3 vs -21.5; p=0.007), despite normal standard echocardiography parameters.
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