Key result
Ketodex provided optimal sedation in 90% of syndromic children with congenital cardiac anomalies undergoing MRI, with a mean recovery time of 17.5 minutes and minimal cardiorespiratory complications.
Why the study?
Paediatric MRI sedation is challenging in uncooperative syndromic children due to an increased risk of periprocedural cardio-respiratory complications, leaving the ideal sedative agent debated.
Does a ketamine-dexmedetomidine combination (ketodex) provide safe and effective sedation for MRI in syndromic children with congenital cardiac anomalies?
Case Report (n=10)
No
Does a ketamine-dexmedetomidine combination (ketodex) provide safe and effective sedation for MRI in syndromic children with congenital cardiac anomalies?
A ketamine-dexmedetomidine combination (ketodex) appears to be a safe and effective agent for MRI sedation in syndromic children with congenital cardiac anomalies.
May support ketodex consideration in this high-risk group; hypothesis-generating and requires prospective trials before adoption.
Safe paediatric sedation in a magnetic resonance imaging (MRI) suite can be challenging. The challenges intensify in uncooperative syndromic children compounded by an accentuated risk of periprocedural cardio-respiratory complications with anaesthetic sedation in this peculiarly predisposed subset. Amidst ardent debates on the ideal sedative agent for paediatric MRI, we report an encouraging application of ketamine-dexmedetomidine combination (ketodex) sedation for MRI in our case-series including syndromic children with coexistent congenital cardiac anomalies.
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Magoon et al. (2022) conducted a case report in Syndromic children with congenital cardiac anomalies requiring MRI sedation (n=10). Ketamine and dexmedetomidine combination (ketodex) was evaluated on Quality of sedation, recovery profile, and periprocedural cardiorespiratory complications. Ketodex provided optimal sedation in 90% of syndromic children with congenital cardiac anomalies undergoing MRI, with a mean recovery time of 17.5 minutes and minimal cardiorespiratory complications.
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