Key result
Influenza A/B infection was a strong independent predictor of ICU admission in pediatric plastic bronchitis (OR 8.563, P=0.001), alongside elevated AST and prolonged hospitalization.
Why the study?
Age-specific clinical profiles and predictors for severe progression in pediatric plastic bronchitis remain poorly characterized.
Cohort (n=180)
Yes
Odds Ratio: 8.563
p-value: p=0.001
In pediatric plastic bronchitis, nursing children are a high-risk subgroup, and influenza infection, elevated AST, and extended hospital stay are key predictors for ICU care.
Age-stratified pediatric plastic bronchitis data identify potential severity predictors; hypothesis-generating for prospective validation before guiding care.
INTRODUCTION AND AIM: Plastic bronchitis (PB) is a rare yet critical respiratory condition in children, with age-specific clinical profiles and predictors for severe progression remaining poorly characterized. METHODS: This multicenter, retrospective study analyzed 180 pediatric PB cases (2014-2025), categorizing patients into nursing (0-3 years), pre-school (>3-6 years), and school-age (≥6 years) groups. We compared demographics, clinical features, laboratory findings, and outcomes across these cohorts. Independent risk factors for ICU admission were identified via multivariate logistic regression. RESULTS: Nursing children presented with more severe respiratory distress, exhibiting significantly higher rates of wheezing, dyspnea, and ICU admission (all P < 0.05) compared to older groups. Mycoplasma pneumoniae detection was more common in pre-school and school-age children (P < 0.001), whereas Human Bocavirus was predominant in nursing children (P = 0.001). Multivariable analysis identified prolonged hospitalization (OR 1.141, P < 0.001), elevated aspartate aminotransferase (AST) (OR 1.004, P = 0.028), and influenza A/B infection (OR 8.563, P = 0.001) as independent risk factors for ICU admission. CONCLUSION: This study, representing the largest PB cohort to date, reveals that nursing children constitute a high-risk subgroup with distinct virologic patterns. Influenza infection, elevated AST, and extended hospital stay serve as key predictors for ICU care, underscoring the necessity of age-specific management protocols in pediatric PB.
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He et al. (2025) conducted a cohort in pediatric plastic bronchitis (n=180). Influenza A/B infection was evaluated on ICU admission (OR 8.563, p=0.001). Influenza A/B infection was a strong independent predictor of ICU admission in pediatric plastic bronchitis (OR 8.563, P=0.001), alongside elevated AST and prolonged hospitalization.
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