Key result
Hemodynamics biomarkers and tissue biomechanics, particularly wall shear stress, are increasingly recognized as important factors in aortic disease development and progression.
Why the study?
Guidelines for aortic wall diseases rely on maximum aortic diameter, yet aortic rupture or dissection can occur at small diameters, highlighting the need to evaluate biomechanics and hemodynamics.
Highlights the potential of combining Computational Fluid Dynamics and 4D MRI to assess wall shear stress as a biomarker for predicting aortic tissue dysfunction in ascending thoracic aortic aneurysms.
May guide aortic aneurysm biomarker research; leaves open clinical adoption without prospective validation.
Guidelines for the treatment of aortic wall diseases are based on measurements of maximum aortic diameter. However, aortic rupture or dissections do occur for small aortic diameters. Growing scientific evidence underlines the importance of biomechanics and hemodynamics in aortic disease development and progression. Wall shear stress (WWS) is an important hemodynamics marker that depends on aortic wall morphology and on the aortic valve function. WSS could be helpful to interpret aortic wall remodeling and define personalized risk criteria. The complementarity of Computational Fluid Dynamics and 4D Magnetic Resonance Imaging as tools for WSS assessment is a promising reality. The potentiality of these innovative technologies will provide maps or atlases of hemodynamics biomarkers to predict aortic tissue dysfunction. Ongoing efforts should focus on the correlation between these non-invasive imaging biomarkers and clinico-pathologic situations for the implementation of personalized medicine in current clinical practice.
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Campisi et al. (2020) conducted a review in Ascending Thoracic Aortic Aneurysms. Hemodynamics biomarkers and tissue biomechanics was evaluated. Hemodynamics biomarkers and tissue biomechanics, particularly wall shear stress, are increasingly recognized as important factors in aortic disease development and progression.
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