Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke‐related brain damage, Alzheimer's disease, and Parkinson's disease. 13C{31P} and 13C{19F} rotational‐echo double‐resonance NMR have been used to map the locations of 17β‐estradiol (estradiol), 17β‐estradiol 17‐benzoate (estradiol benzoate), and 17β‐2‐(1‐adamantyl)estradiol (adamantyl estradiol) in 19F‐labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency. Drug Dev. Res. 66:99–102, 2006.
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