BSA and fibrinogen adsorption to ultrathin nonfouling coatings was investigated using surface plasmon resonance spectroscopy. The nonfouling coatings were prepared by pulsed plasma polymerization (pp) of di(ethylene glycol) monovinyl ether (EO2). The pp-EO2 coatings were characterized by X-ray photoelectron spectroscopy and atomic force microscopy. The nonfouling properties of the pp-EO2 coatings were found to correlate with details of the surface chemistry and with the film thickness. BSA and fibrinogen exhibited different adsorption behaviors. We identified the threshold value of the thickness of pp-EO2, above which the films showed excellent antifouling properties. The mechanism by which these films resist protein adsorption is discussed.
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Chu et al. (2006) studied this question.
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