Various 2‐substituted purine and pyrrolo[2,3‐d]pyrimidine 2′‐deoxyribonucleosides with methylthio (13a), chloro (13b), methoxy (9b), and oxo (2, 3) substituents at C(2) are prepared. They are obtained eitherviastereoselective nucleobase‐anion glycosylation or by base transformation. A three‐step synthesis of the unknown 2′‐deoxyisoinosine (2) from 2′‐deoxyguanosine (15) is described. Compound2as well as its 7‐deazapurine derivative3exhibit strong fluorescence.
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Seela et al. (1994) studied this question.
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