Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary

Figures

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  Fig. 1. Flowchart of the patient selection

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  Fig. 2. Definition of adherence and persistence

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  Fig. 3. Survival of patients with or without taking ChEis. The median survival of ChEi-non-fillers was 2.50 years. In all groups of the ChEi-fillers, the median survival was more than 4 years (p < 0.0001). Among the ChEi-fillers, significant difference was found between ChEi vs ChEi-mem-noot (combination of ChEi, memantine, and nootropics) (p < 0.0004) and ChEi-noot vs. ChEi-mem-noot (p < 0.0027). (Combined used means that patients were filled with the drugs at least once during the study period, but not necessarily used the drugs simultaneously.) Kaplan–Meier curves, log rank test. In addition to the deceased patients, the number at risk is also decreased by patients whose observation was shorter than the study period. mem memantine, noot nootropics

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  Fig. 4. Persistence for ChEis. Kaplan–Meier curves, log rank test, p < 0.0001

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  Fig. 5. Adherence and persistence of all ChEi filler patients. The adherence was categorized in 3 groups on the X axis, while persistence was visualized as a continuous time line in days on the Y axis. Each dot represents a patient, donepezil was marked with grey, rivastigmine with blue, and switcher with purple