α,β-Epoxy ketones, prepared using the polyleucine catalysed asymmetric epoxidation of enones, can be converted into α-substituted β-hydroxy ketones via carbonyl alkylation with Grignard reagents followed by ytterbium triflate catalysed semi-pinacol rearrangement of the resulting epoxyalcohols.
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Bickley et al. (2001) studied this question.
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