Reversible renal damage due to glue sniffing.

Exacerbation of diazepam-induced phlebitis by oral penicillamine Penicillamine, a heavy metal antagonist, is used in the treatment of Wilson's disease, cystinuria, rheumatoid arthritis, and various other conditions.Adverse reactions to the drug are many and frequent and range in severity from gastrointestinal distress, stomatitis, unpleasant skin odours, and rashes to proteinuria, leucopenia, and thrombocytopenia.1 Up to one-third of patients given the drug for rheuma- toid arthritis have to discontinue treatment because of toxicity.'Intravenous diazepam is widely used as a sedative, muscle relaxant, and anticonvulsant.Local complications with this drug, including pain at injection site, phlebitis, and thrombophlebitis, have likewise been reported frequently.2We describe a patient who developed phlebitis from intravenous diazepam.The phlebitis resolved with local heat but recurred on two separate occasions after oral penicillamine.