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January 1, 1982Antimicrobial Agents and Chemotherapy

Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity

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Key result

Oral therapy with ribavirin-2',3',5'-triacetate and (S)-DHPA increased mean survival time in murine rotavirus gastroenteritis, but did not increase the survivor rate.

Population

MA-104 cells infected with simian (SA11) rotavirus and mice with murine rotavirus gastroenteritis

Comparison

RNA virus inhibitors including ribavirin… vs Control (untreated)

Design

Preclinical

Authors

DSDonald F. SmeeUtah State UniversityRSR. W. SidwellSouthern Research InstituteSCS M ClarkUtah State University

Discussion

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Implication

Does not improve survivor rate despite longer survival in murine model; hypothesis-generating and requires validation before clinical consideration.

Structured PICO

P
Population
MA-104 cells infected with simian (SA11) rotavirus and mice with murine rotavirus gastroenteritis
I
Intervention
RNA virus inhibitors including ribavirin, 3-deazaguanine (3-DG), 3-deazauridine, and 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA]
C
Comparator
Control (untreated)
O
Outcome
Infectious SA11 virus yields in vitro, mean survival time and survivor rate in vivosurrogate

Selected RNA virus inhibitors reduce rotavirus yield in vitro and improve survival time and weight gain in a murine model of rotavirus gastroenteritis.

Cite This Study

Smee et al. (1982) studied Simian (SA11) rotavirus infections and murine rotavirus gastroenteritis. RNA virus inhibitors (ribavirin, 3-DG, 3-deazauridine, and (S)-DHPA) vs. control was evaluated on Mean survival time and survivor rate. Oral therapy with ribavirin-2',3',5'-triacetate and (S)-DHPA increased mean survival time in murine rotavirus gastroenteritis, but did not increase the survivor rate.

synapsesocial.com/papers/6a9dcfd3bc661ee181a589a4https://doi.org/10.1128/aac.21.1.66
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