Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight

Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF 3 radical. 1. Introduction 2. Transition-Metal-Free Activation of Sodium Triflinate 3. Photochemical Activation of Sodium Triflinate 4. Conclusions and Outlook