Key result
Intraperitoneal injection of oxytocin and atosiban was evaluated for its effects on carbonic anhydrase and acetylcholinesterase enzyme activities in rat liver and kidney tissues.
This preclinical study investigated the effects of oxytocin and atosiban on CA and AChE enzyme activities in rat liver and kidney tissues.
Hypothesis-generating in rat liver and kidney; human studies needed before any clinical relevance for oxytocin or atosiban.
The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in liver and kidney tissues of rats. For this purpose, four different groups, each consisting of six rats (n = 6), were formed (control group, OT administered group, atosiban administered group, and both OT and atosiban administered group). The rats were necropsied 60 min after intraperitoneal injection of chemicals into the rats. Liver tissues of rats were extracted. CA and AChE enzyme activities were measured for each tissue by using hydratase, esterase, and acetylcholiniodide methods. Activity values for each enzyme obtained were statistically calculated.
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Koçyiğit et al. (2017) studied this question. Oxytocin and atosiban vs. Control group was evaluated on Activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in liver and kidney tissues. Intraperitoneal injection of oxytocin and atosiban was evaluated for its effects on carbonic anhydrase and acetylcholinesterase enzyme activities in rat liver and kidney tissues.
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