Key result
Total physical activity was significantly associated with increased risk of idiopathic scoliosis (OR 1.72; 95% CI 1.11-2.68; P=.015), while low-intensity and moderate-to-vigorous activity were not.
Why the study?
Scoliosis can lead to chronic pain and reduced quality of life, but the relationship between physical activity and scoliosis is debated.
Does genetically predicted physical activity increase the risk of idiopathic scoliosis?
Observational
Does genetically predicted physical activity increase the risk of idiopathic scoliosis?
Total physical activity may be a causal risk factor for idiopathic scoliosis based on Mendelian randomization, warranting further mechanistic exploration.
Answers are grounded in this paper and cite their sources.
Total activity may increase scoliosis risk; hypothesis-generating and requires prospective validation before clinical relevance.
Scoliosis, marked by abnormal spinal curvature, is common in adolescents and can lead to chronic pain and reduced quality of life. The relationship between physical activity and scoliosis is debated. In this study, we aim to investigate the causal relationship between physical activity levels and idiopathic scoliosis risk using the Mendelian randomization (MR) approach. Two-sample MR analyses evaluated low-intensity (low-intensity physical activity [LIPA]), moderate-to-vigorous (MVPA), and total physical activity (TLA) as exposures, selecting genetic instruments based on their associations. Total physical activity significantly associated with idiopathic scoliosis (OR = 1.72; 95% CI = 1.11-2.68; P = .015), whereas LIPA and MVPA showed no significant associations. Reverse MR found no idiopathic scoliosis impact on activity levels. Multivariable MR showed no significant activity-scoliosis links. Total physical activity emerges as an idiopathic scoliosis risk factor, warranting mechanistic exploration. LIPA and MVPA do not causally link to scoliosis. Idiopathic scoliosis does not influence activity levels.
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Wang et al. (2024) conducted an observational in idiopathic scoliosis. Physical activity levels was evaluated on idiopathic scoliosis (OR 1.72, 95% CI 1.11-2.68, p=.015). Total physical activity was significantly associated with increased risk of idiopathic scoliosis (OR 1.72; 95% CI 1.11-2.68; P=.015), while low-intensity and moderate-to-vigorous activity were not.
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