Key result
In diabetic rats, the presence of perivascular adipose tissue significantly enhanced 5-hydroxytryptamine-induced arterial contraction compared to PVAT-free arteries, mediated by increased hydrogen peroxide production.
Why the study?
Does catalase reduce 5-HT-induced contraction in diabetic rat gracilis arteries with perivascular adipose tissue?
Does catalase reduce 5-HT-induced contraction in diabetic rat gracilis arteries with perivascular adipose tissue?
Answers are grounded in this paper and cite their sources.
Diabetes converts the regulatory role of perivascular adipose tissue from relaxation to H2O2-mediated contraction in rat skeletal muscle arteries.
This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).
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Emilova et al. (2016) studied Diabetes (STZ-induced). Perivascular adipose tissue (PVAT) vs. PVAT-free arteries was evaluated on 5-HT-induced contraction at 10^-5 M (% of 60 mM KCl contraction) in diabetic rats (p=<0.01). In diabetic rats, the presence of perivascular adipose tissue significantly enhanced 5-hydroxytryptamine-induced arterial contraction compared to PVAT-free arteries, mediated by increased hydrogen peroxide production.
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