Key result
Multiple system atrophy was associated with increased CD4+/CD8+ T cell ratio, natural killer cells, and CD28 expression, but decreased CD8+ T cells and HLA-DR expression compared to healthy controls (p < 0.05).
Why the study?
Immune involvement is suggested in the pathology of multiple system atrophy, but research on detailed peripheral immune indices remains relatively sparse.
Are peripheral immune traits altered in patients with multiple system atrophy compared to healthy controls?
Case-Control (n=82)
Are peripheral immune traits altered in patients with multiple system atrophy compared to healthy controls?
Patients with multiple system atrophy exhibit dysregulation of cellular immunity, characterized by altered T cell subsets and activation markers.
Hypothesis-generating for immune biomarkers in MSA; prospective studies needed before diagnostic or therapeutic consideration.
A growing body of evidence suggests immune involvement in the pathology of multiple system atrophy (MSA). Research on detailed peripheral immune indices, however, is relatively sparse, and is one of the intriguing aspects of MSA yet to be elucidated. A total of 26 MSA patients and 56 age-and sex-matched healthy controls (HC) were enrolled in the current case-control study to delineate the peripheral immune traits of MSA patients. The ratio of CD4+/CD8+ T cells, natural killer cells, CD28 expression on both CD4+ T cells and CD8+ T cells increased in MSA patients compared to HC, but CD8+ T cells and active marker (HLA-DR) expression on total T cells decreased (p < 0.05). This study sheds light on the dysregulation of cellular immunity in MSA, pointing to future mechanistic research.
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Gong et al. (2023) conducted a case-control in Multiple system atrophy (MSA) (n=82). Multiple system atrophy vs. Healthy controls was evaluated on Peripheral immune traits including CD4+/CD8+ T cell ratio, natural killer cells, CD28 expression, CD8+ T cells, and HLA-DR expression (p=< 0.05). Multiple system atrophy was associated with increased CD4+/CD8+ T cell ratio, natural killer cells, and CD28 expression, but decreased CD8+ T cells and HLA-DR expression compared to healthy controls (p < 0.05).
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