Study of relationship between CRP, bilirubin and selected anthropometric parameters with hypertension

Background: There are many recent studies showing that hypertension, and cardio-vascular disease is linked to inflammation. The higher CRP levels are significantly correlated with hypertension. CRP estimation is used as a surrogate marker in evaluation and predicting the prognosis of all hypertensive patients. Many of the epidemiologic studies had shown the association of CRP levels with future cardiovascular events and hypertension. Bilirubin has been shown to be an effective antioxidant both in vitro and in vivo. The excess body fat and distribution is an important contributor to the association between obesity and high BP. Aims and objectives: The objective was to study the relationship between CRP, Bilirubin and selected anthropometric parameters among both hypertensive and non hypertensive subjects. Methods: We have conducted a hospital based descriptive observational study using purposive non random sampling method on 150 subjects; 87 hypertensive and 77 were non hypertensive. Age, systolic BP, diastolic BP, weight, height, waist circumference, hip circumference, SAD, total Bilirubin, T cholesterol, HDL-C, Triglycerides, LDL-C were primary continuous variables. BMI, WHR, WHtR were taken as secondary variables. Results: CRP, Waist circumference, WHtR and SAD have a positive correlation with both systolic and diastolic BP. Odds ratio was 12.18 for CRP. Total Bilirubin levels have a negative correlation with systolic and diastolic BP. Odds ratio was 7.81. Diastolic BP had positive correlation with Weight, Hip circumference and BMI. Conclusion: We had demonstrated elevated CRP, low Bilirubin levels, abnormal SAD and Waist circumference were associated with blood pressure levels. These parameters are useful and cost-effective tool for predicting and evaluating Hypertension.