Key result
Computational fluid dynamic modeling demonstrated that the aspiration ability of a thrombectomy device is independent of initial thrombus size, but aspiration time increases with larger thrombi, and an aspiration pressure below 30 kPa may fail to completely remove the thrombus.
Why the study?
Does aspiration pressure, thrombus size, and thrombus viscosity affect the volume of aspirated thrombus in a computational model of coronary aspiration thrombectomy?
Does aspiration pressure, thrombus size, and thrombus viscosity affect the volume of aspirated thrombus in a computational model of coronary aspiration thrombectomy?
Computational modeling demonstrates that successful aspiration thrombectomy depends primarily on applying sufficient aspiration pressure (>30 kPa) and the viscosity of the thrombus, rather than its initial size.
Supports modeling-based pressure thresholds for thrombectomy devices; leaves open validation in human coronary interventions.
It is important to thoroughly remove the thrombus within the course of aspiration thrombectomy; otherwise, it may lead to further embolization. The performance of the aspiration thrombectomy device with a generic geometry is studied through the computational approach. In order to model the thrombus aspiration, a real left coronary artery is chosen while thrombi with various sizes are located at the bifurcation area of the coronary artery and, depending on the size of the thrombus, it is stretched toward the side branches. The thrombus occupies the artery resembling the blood current obstruction in the coronary vessel similar to the situation that leads to heart attack. It is concluded that the aspiration ability of the thrombectomy device is not linked to the thrombus size; it is rather linked to the aspiration pressure and thrombus age (organized versus fresh thrombus). However, the aspiration time period correlates to the thrombus size. The minimum applicable aspiration pressure is also investigated in this study.
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Soleimani et al. (2015) studied Acute Myocardial Infarction. Aspiration thrombectomy device (computational model) was evaluated on Aspirated thrombus volume and aspiration time. Computational fluid dynamic modeling demonstrated that the aspiration ability of a thrombectomy device is independent of initial thrombus size, but aspiration time increases with larger thrombi, and an aspiration pressure below 30 kPa may fail to completely remove the thrombus.
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