Key result
Metabolic connectivity within a network of six working memory-relevant Brodmann areas was significantly stronger in young healthy subjects with above-median verbal working memory performance (P=0.016).
Why the study?
Does metabolic connectivity in resting state FDG-PET correlate with verbal working memory performance in healthy young adults?
Cross-Sectional (n=35)
Yes
Does metabolic connectivity in resting state FDG-PET correlate with verbal working memory performance in healthy young adults?
p-value: p=0.016
Metabolic connectivity modeling using sparse inverse covariance estimation on resting state FDG-PET data can identify network correlates of healthy cognitive function, specifically verbal working memory.
Correlates FDG-PET metabolic networks with verbal working memory; hypothesis-generating and requires prospective validation before any clinical application.
Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.
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Zou et al. (2015) conducted a cross-sectional in Healthy cognitive function (verbal working memory) (n=35). Above-median verbal working memory performance vs. Below-median verbal working memory performance was evaluated on Average strength of metabolic connectivity edges within a network of 6 working memory-relevant Brodmann areas (p=0.016). Metabolic connectivity within a network of six working memory-relevant Brodmann areas was significantly stronger in young healthy subjects with above-median verbal working memory performance (P=0.016).
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