A highly efficient synthesis of a phenanthridine alkaloid, trispheridine (1) has been achieved in a 74% overall yield in a four-step sequence. The key step is the construction of a tetrahydrophenanthridine based on a microwave -assisted thermal electrocyclic reaction of an aza 631-electron system including the benzene double bond.
No takes yet. Share an insight, caveat, or question.
Hibino et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: