Key result
Percutaneous closure of the left atrial appendage was reported as a potential alternative to chronic oral anticoagulation for stroke prevention in a patient with high-risk AF and HHT.
Why the study?
Does percutaneous closure of the left atrial appendage prevent stroke in patients with atrial fibrillation and hereditary hemorrhagic telangiectasia?
Case Report (n=1)
Does percutaneous closure of the left atrial appendage prevent stroke in patients with atrial fibrillation and hereditary hemorrhagic telangiectasia?
Left atrial appendage closure may serve as a viable alternative to oral anticoagulation for stroke prevention in patients with atrial fibrillation and hereditary hemorrhagic telangiectasia who have a high bleeding tendency.
May warrant consideration in select high-bleeding-risk AF-HHT cases; leaves open prospective validation for stroke prevention.
Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting millions of individuals worldwide, and a major risk factor for disabling cerebral embolic stroke. Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disorder, characterized by vascular abnormalities with high-bleeding tendency and therefore intolerance for oral anticoagulation. We report a case of percutaneous closure of the left atrial appendage, which might be a good alternative strategy instead of chronic oral anticoagulation to protect patients with high-risk AF and HHT from cerebral embolic strokes.
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Velthuis et al. (2012) conducted a case report in Atrial Fibrillation and Hereditary Hemorrhagic Telangiectasia (n=1). Percutaneous closure of the left atrial appendage vs. Chronic oral anticoagulation was evaluated on Cerebral embolic strokes. Percutaneous closure of the left atrial appendage was reported as a potential alternative to chronic oral anticoagulation for stroke prevention in a patient with high-risk AF and HHT.
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