Enzyme mimicry: Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular nonbonding Se⋅⋅⋅O interaction. Both 1 and 2 show excellent glutathione peroxidase-like catalytic activity.
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Zade et al. (2004) studied this question.
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