The autoxidation of strophanthidin (I) in concentrated solution yields a neutral main product, aglycone A. Its structure was established as 10β‐hydroxy‐19‐nor‐periplogenin (II). The novel cardenolide arises from strophanthidin in a rearrangement reaction involving loss of carbon dioxide; the mechanism is discussed.
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Wartburg et al. (1962) studied this question.
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