A series of new chiral diselenides with a N‐atom in the side chain was prepared by a short synthetic sequence ( Scheme 1 ). Only 1 mol‐% of these diselenides catalyzed very effectively the diethylzinc addition to various aromatic and α,β‐unsaturated aldehydes yielding the secondary alcohols in up to 98% ee ( Scheme 2 and Tables 1 and 2 ). An asymmetric amplification was observed with these catalysts. Detailed NMR studies were performed to characterize the catalytically active species.
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Wirth et al. (1996) studied this question.
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