Indonesian Medicinal Plants. XI. Chemical Structures of Caesaldekarins a and b, Two New Cassane-Type Furanoditerpenes from the Roots of Caesalpinia major (Fabaceae).

Five new cassane-type furanoditerpenes named caesaldekarins a (1), b (2), c, d, and e were isolated from the roots of Caesalpinia major (Fabaceae), an Indonesian medicinal plant. The chemical structures of 1 and 2 have been elucidated on the bases of physicochemical evidence and chemical derivations. The major diterpenoid caesadekarin a (1) was shown to inhibit mitogen responses of mouse spleen cells and interleukin-1 production.